1st Latin American Symposium on the Molecular Mechanisms of Skeletal Mineralization

1o Latin American Symposium on the Molecular Mechanisms of Skeletal Mineralization
May 19th to 21st, 2010

Room: Cedro I

May 19th, 2010 – 11:00 to 12:00
LEC-1 - Chairperson: José Luis Millán

Molecular determinants of skeletal and pathologic mineralization
Marc D. McKee McGill University, Montreal,  Canada

May 19th, 2010 – 08:30 to 10:00

SE-01 – Osteoblast / osteoclast / chondroblast biology
Chairman:  José Mauro Granjeiro

Osteocytes: the third cell of bone gets to the center stage
Teresita Bellido, Indiana University School of Medicine, Indiana, USA

Role of Connexin 43 expression in osteoblastic cells on cell viability and bone material properties
Lilian I. Plotkin, Indiana University School of Medicine, Indiana, USA

The new mineralized tissue formed around hydroxyapatite containing biocomposites: a source for studies on the biomineralization processes
Marcos Farina, UFRJ, Brazil

BMP-induced signaling requires cytoskeleton rearrangement in osteoblast
José Mauro Granjeiro, UFF, Brazil

Signal transduction as a new strategy for developing “smart biomaterials”
Willian Zambuzzi, UNICAMP, Brazil

May 19th, 2010 – 14:00 to 16:00
SE-02 – Enzymatic mechanisms of calcification and regulation
Chairman: Francisco de Assis Leone

Rat osseous plate alkaline phosphatase: a search for its role in biomineralization.
Pietro Ciancaglini, FFCLRP, USP

Proteoliposomes Carrying Alkaline Phosphatase and Nucleotide Pyrophosphatase/ Phosphodiesterase-1 as Matrix Vesicles’ Biomimetics
Ana Maria Sper Simão, FFCLRP, USP

Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function
Manisha C. Yadav, Sanford-Burnham Institute for Medical Research, La Jolla, California, USA

The structural and functional significance of the calcium-binding site in mammalian alkaline phosphatases
Tina Kiffer-Moreira, Sanford-Burnham Institute for Medical Research, La Jolla, California, USA

May 19th, 2010 – 18:30 to 20:30
SE-03 – Ectopic calcification
Chairman: José Luis Millán

Vascular calcification: role of alkaline phosphatase
Marc F. Hoylaerts, University of Leuven, Leuven, Belgium

Leads and Target Validation for the Prevention and Treatment of Vascular Calcification
José Luis Millán, Sanford-Burnham Institute for Medical Research, La Jolla, California, USA   

Redox processes underlying vascular and aortic valve calcification
Francisco Laurindo, INCOR, SP , Brazil

Coronary Artery Calcification in Kawasaki Disease
Adriana H. Tremoulet, University of California, San Diego, USA   

May 20th, 2010 – 14:00 to 16:00
SE-04 – Metabolic bone diseases/Pathological mineralization
Chairman: João M. Pizauro

Bone and Mineral Diseases Associated with Inorganic Pyrophosphate Dysregulation
Deborah Wenkert, Shriners Hospitals for Children, St. Louis, Missouri, USA

Osteogenesis Imperfecta:  Molecular aspects, clinical overview and response to treatment
Cristina Tau, Centro de Osteopatías, Buenos Aires,

A search for metabolic changes in tibial dyschondroplasia
João M. Pizauro, FCAVJ, UNESP, Brazil

RANKL System as the Common Mechanism of Osteoporosis and Vascular Calcification
Mariana Kiomy Osako, Osaka University, Japan

May 20th, 2010 – 18:30 to 19:30
LEC-2 - Chairperson: Adalberto Luiz Rosa

Adult Stem Cells and Nanomaterials in Skeletal Tissue Engineering and Regeneration
Rocky S. Tuan, Pittsburgh School of Medicine, PA, USA

May 21st, 2010 – 08:00 to 10:30
SE-05 – Pathophysiologiy of bone loss
Chairman: Adriana A. Rezende

Looking beyond bone mass: the concept of bone quality and how we can measure it
Cesar Bogado, Instituto de Investigaciones Metabólicas -IDIM, Buenos Aires, Argentina

Diabetes melitus and the pathophysiology of bone loss
Adriana A. Rezende, FF-UFRN, Brazil

Cytokine control of bone loss revisited: how pro- vs anti-inflammatory, Th1 vs Th2 & Th17 vs Tregs archetypes determine periodontitis outcome
Gustavo P. Garlett, FOB-USP, Brazil

The role of RANKL, OPG and MMPs in bone remodeling
Rodrigo Cardoso de Oliveira, FOB-USP, Brazil

Inflammation and Diabetic Bone Loss
Marela A. G. Ururahy, FF-UFRN, Brazil

May 21st, 2010 – 11:00 to 12:00
LEC-3 - Chairperson: Pietro Ciancaglini

Heritable disorders of the RANKL/OPG/RANK/NF-kB signaling pathway
Michael Whyte Washington University School of Medicine, St. Louis, Missouri, USA

May 21st, 2010 -14:00 to 16:00
SE-06 – Biomaterials/BMP/ Bioestimulation
Chairman: Adalberto L. Rosa/Paulo T. De Oliveira

Calcified Tissues: From Basic Studies to Novel Biomaterials with Intelligent Surfaces
Antonio Nanci, Université de Montréal, Canada

Current Trends on Endosseous Implant Bulk and Surface Design
Paulo Guilherme Coelho, New York University, USA

A platelet-rich plasma-like growth factor-protein mixture inhibits development of the osteogenic phenotype in osteoblastic cell cultures
Paulo Tambasco de Oliveira, FORP-USP, Brazil

Inflammatory response and biomaterials
Débora Tavares, UFRJ/COPPE

Applications of natural rubber in bone regeneration
Carlos F. O. Graeff,  UNESP,  Bauru, Brazil

May 21st, 2010 – 18:30 to 19:30
LEC-4 – Closing Conference
Chairperson: José Mauro Granjeiro

Phosphoproteomics and Phosphokinome Approaches for Monitoring Osteoblast Behavior
Thomas Halder, TopLab GmbH, Germany


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