Scientific Program

46ª SBBq Annual Meeting

27th to 30th July, 2017

Final Program - click to download


Thursday - July 27

8h - 16h: Mini-Courses

MC1: RNA therapeutics

Karen Cristiane Martinez de Moraes, IB–UNESP, Rio Claro.


MC2: Analysis of protein families using sequence alignment tools and site-directed mutagenesis

Lucas Bleicher, UFMG


MC3: Advanced mass spectrometry-based proteomics for post-translational modifications (PTMs) analysis

Jose Cesar Rosa, FMRP-USP and Giuseppe Palmisano, IB-USP


MC4: Use of Information and knowledge technologies in experimental biochemistry classes

Guilherme Marson, IQ-USP


MC5: Ludic development of android applications as a teaching strategy

Gabriel Hornink, Unifal, Minas Gerais


MC6: Introduction to cryo-electron microscopy

Marin Van Heel, Imperial College London and Rodrigo V. Portugal (LNNano/CNPEM)


16h30 - 17h30: Short-talk

An enterprising scientist in the scientific communication startup “Mind the Graph”

Fabricio Pamplona, Founder.


18h -19h:  Opening Conference

Chair:  Richard Garratt, IFSC-USP


CryoEM of Molecular Machines at Near Atomic Resolution

Wah Chiu, Baylor College of Medicine


Friday - July 28, 8h30 - 10h30


SP.01 – Modulation of Protein Kinase Function in Human Health and Plant Biotechnology

Chair: Rafael Counago, UNICAMP


Human kinases and RNA regulation

Katlin Brauer Massirer,Centro de Biologia Molecular e Engenharia Genética – UNICAMP


Research, Development & (Open) Innovation at Aché Laboratórios Farmacêuticos: Exploring Understudied Kinases with the Structural Genomics Consortium

Cristiano Ruch Werneck Guimarães, Aché Laboratórios Farmacêuticos


Inverse modulation of antiviral and antibacterial immunity by immune RLK complexes

Elizabeth P B Fontes, Bioagro - Universidade Federal de Viçosa


Chemical probe development for protein kinases STK10 and SLK

Jon Elkins, University of Oxford, UK


SP.02 - Challenges for the Present and Future of Brazilian Science

Chair: Glaucius Oliva, IFSC-USP, SBBq President


Mario Neto Borges, CNPq

Carlos H. Brito, FAPESP

Jorge A. Guimarães, Embrapii


SP.03 – Diversity and Function of Microbiomes

Chair: Aline Maria da Silva, IQ-USP


A microbial-molecular view of what happens when organic waste from a Zoo is composted

João Carlos Setubal, Instituto de Química, USP


Rhizosphere microbiome and plant disease suppression

Rodrigo Mendes, Embrapa Meio Ambiente


Targeting new plant growth-promoting (PGP) microbes from the sugarcane microbiome

Paulo Arruda, UNICAMP


The Human Gut Microbiome

Christian Hoffmann, Faculdade de Farmácia, USP


SP.04 - SBBq-GE Healthcare: 21o Prize for Young Talent in Life Science

Chair: Richard C. Garratt, IFSC-USP, SBBq Vice-President


Yeast GPCR signaling reflects the fraction of occupied receptors, not the number.

Alan Bush, Universidad De Buenos Aires


From science to industry - metabolic engineering and adaptive evolution of Saccharomyces cerevisiae for second-generation (2G) ethanol production

Leandro Vieira Dos Santos, Universidade Estadual de Campinas


Independent molecular pathways control cell survival and genomic stability after UV irradiation

Maria Belen Federico, Universidad de Buenos Aires


Phytochrome B Integrates Light and Temperature Signals in Arabidopsis.

Martina Legris, Universidad de Buenos Aires


FNDC5/irisin corrects memory defects in animal models of Alzheimer’s disease

Mychael Vinícius Da Costa Lourenço, Universidade Federal do Rio De Janeiro


Friday - July 28,11h – 12h


Conference 1

Chair: Anibal E. Vercesi, UNICAMP


Genome Editing of Protist Parasites by CRISPR/CAS9

Roberto Do Campo, University of Georgia


Conference 2

Chair: Hernan F. Terenzi, UFSC


Chemical Pharmacology of Protein Conjugates

Gonçalo Bernardes, University of Cambridge


Conference 3

Chair: José Ribamar dos Santos Ferreira Júnior, EACH-USP


Dissecting molecular mechanism of Hematopoietic Stem Cell (HSC) formation during development

Michelina Iacovino, University of California, Los Angeles


Friday - July 28, 14h - 16h


SP.05 - Structural Biology - en route towards cryo-electron microscopy

Chair: Rodrigo V. Portugal - LNNano/CNPEM / Brasil


The Structure of the Septin Heterofilament

Richard Garratt - IFSC-USP / Brasil


Active Glutaminase C Self-assembles into a Supra-tetrameric Oligomer that is Disrupted by an Allosteric Inhibitor: Implications for Cancer Metabolism

Sandra Martha Gomes Dias - LNBio/CNPEM / Brasil


Conformational Variability of Macromolecular Complexes: Lessons from Cryo-EM

Mario Borgnia - NIH Molecular Microscopy Consortium at the Research Triangle Park,  USA


CryoEM structure of a bacterial killing T4SS outer membrane complex

Germán Sgro, Institute of Structural and Molecular Biology – Birkbeck/UCL, UK



SP.06 – Mechanisms for Neurodegeneration and Neuroprotection: Impacts on Therapy for Degenerative Disorders.

Chair:  Maria De Fátima Dias Costa (UFBA)


Bradykinin signaling in the brain: Stimulation of neurogenesis and neuroprotection

Henning Ulrich, Institute of Chemistry, USP


α-Synuclein oligomers evoke non-motor and motor symptoms of Parkinson’s disease in mice

Cláudia P. Figueiredo, Faculdade de Farmácia, UFRJ


Neuroprotective role of guanosine in brain injury

Diogo Onofre de Souza, UFRGS


Neurogenic, neuroprotective and immunomodulatory effects of the pro-estrogenic compound agathisflavone

Victor Diogenes Amaral da Silva, Instituto de Ciências da Saúde, UFBA,INNT



SP.07 –SBBq Conesul Symposium: Young Researcher Platform Session 1

Chair: Miguel Castanho, Instituto de Medicina Molecular, Lisbon, Portugal


Calcium-sensing receptor (CASR) activation leads to mitochondrial dysfunction in LS14 preadipocytes

Roberto Bravo-Sagua, University of Chile


Relevance of endoplasmic reticulum stress in alpha-synuclein oligomerization/aggregation in Parkinson’s Disease

Valentin Coppola Segovia, Universidade Federal do Paraná


Human HSP90 structure shift by EGCG interaction

Carolina Colleti, Universidade Federal de São Carlos


Experimental evolution of the pathogenic yeast Candida albicans under hypoxia and heat shock reveals that environmental conditions modifies the methylation pattern of its mitochondrial genome

Thais Fernanda Bartelli, Universidade Federal de São Paulo


Mitochondrial metabolism and ER-mitochondrial coupling increase during doxycycline-induced mitochondrial stress in HeLa cells

Camila Paz López Crisosto, Univ. Chile



SP.08 – Phosphatases in Cancer

Chair: Fábio L. Forti, IQ-USP


Dual-Specificity MAP kinase phosphatases are important modulators of oncogenic signalling through the Ras/ERK pathway

Stephen M. Keyse, Division of Cancer Research, Ninewells Hospital & Medical School, UK


ACP1 phosphatase as a druggable target in cancer

Carmen V. Ferreira, Instituto de Biologia, UNICAMP


Dual-specificity phosphatases in metabolic reprogramming of pancreatic cancer

Vanessa S. Silveira, Faculdade de Medicina de Ribeirão Preto, USP


DUSP3 phosphatase contributes for genomic stability of cancer cells

Fábio L. Forti, Instituto de Química, USP



Saturday - July 29, 8h30 - 10h30


SP.09 – Systems Biology and Biomarkers for Human Disorders

Chair: Daniel Martins-de-Souza, UNICAMP


Post-translational modifications in health and disease

Giuseppe Palmisano, Instituto de Biociências, USP


Molecular signatures of Parkinson’s Alzheimer’s and Bipolar diseases: Altered Regulons, Molecular Targets and Innovative Therapeutics Interventions

Fabio Klamt, Instituto de Ciências Básicas da Saúde, UFRGS


Structural and Semantic Speech Analysis Provides Biomarkers of Schizophrenia, Bipolar Disorder and Alzheimer's Disease

Sidarta Ribeiro, Instituto do Cérebro, UFRN


New insights about brain malformations using iPS cells

Stevens Rehen, Instituto D'or de Pesquisa e Ensino and ICB-UFRJ



SP.10 - Protein and Genome Homeostasis

Chair: Carlos Henrique Inácio Ramos, UNICAMP


Chaperoning the proteome

Walid Houry, University of Toronto, Canada


J co-chaperones: structure and interaction with the 70 kDa heat shock protein Hsp70

Carlos Henrique Inácio Ramos, UNICAMP


Structure-function relationship of human mortalin – the mitochondrial Hsp70 – and the interaction with its Hep1 co-chaperone

Julio Cesar Borges, USP-SC


Chaperones and Leishmania spp. telomere homeostasis

Maria Isabel Nogueira Cano, UNESP



SP.11 – Portugal-Brazil Symposium: Biochemistry and Molecular Biology in Science Teaching

Chair: Vera Maria Treis Trindade, UFRGS


Dealing with the challenge of building a Biochemistry Program in an integrated Medical curriculum. The need for new didactics, new focal interests, and new connections to other disciplines.

Miguel Castanho, Faculdade de Medicina, Universidade de Lisboa, Lisboa


The Multilayered Challenges of Contemporary Graduate Training in Biochemistry and Experimental Biology

João Ramalho Santos, Universidade de Coimbra


Tactile Models and Games as Learning Tools for Topics of Molecular and Cell Biology

Nelma Regina Segnini Bossolan, Instituto de Fisíca de São Carlos, USP


Science For Education: A New model of Translacional Research Inspired by Education

Roberto Lent, Instituto de Ciências Biomédicas, UFRJ



SP.12 – Molecular basis of demyelinating peripheral neuropathies

Chair: Flavio Alves Lara, Instituto Oswaldo Cruz, RJ


The role of vesicular transfer between glia and neurons in the regulation of axonal regeneration in the peripheral nervous system

Felipe Court, Universidad Mayor, Facultad de Ciencias, Chile


Biological Behavior of Mesenchymal Stem Cells on Poli-ε-caprolactone Filaments and a Strategy for Tissue Engineering of long segments of Peripheral Nerves

Victor Tulio Rezende, IBCCF-UFRJ


Peripheral neuropathy associated to Zika virus.

Fernando Bozza, Instituto Nacional de Infectologia Evandro Chaves, Fiocruz


Central Metabolism as a New Target in the Control of Leprosy Neuropathy

Flavio Alves Lara, Instituto Oswaldo Cruz, RJ



Saturday - July 29, 11h – 12h


Conference 4

Chair: Marcio Dias, ICB-USP


The structure and mechanism of bacterial multi-drug efflux pumps

Ben F. Luisi, University of Cambridge-UK


Conference 5

Chair: Paulo Arruda, UNICAMP


From disease genetics to chemical intervention: Overcoming barriers to the discovery of novel drug targets

Opher Gileadi, Structural Genomics Consortium, University of Oxford/ UNICAMP.


Conference 6

Chair: Gabriel Horninck, Unifal


The Internet of things, mobile devices and the promising future for Science Education

Eduardo Galembeck, UNICAMP



Saturday - July 29,14h - 16h


SP.13 – Zika virus: Structural, Immunological and neurological aspects

Chair: Glaucius Oliva, IFSC-USP


Structural and Immunological Properties of Inactivated Zika Virus Particles

Jerson Lima da Silva, Instituto de Bioquímica Médica, UFRJ


Detecting important positions in flaviviruses proteins by statistical analysis of conserved domains

Lucas Bleicher, UFMG


Crystal structure of Zika virus RNA-dependent RNA-polymerase

Glaucius Oliva, Instituto de Física de São Carlos, USP


The Use of Brain Organoids to Measure the Impact of Zika Virus on Microcephaly

Patrícia Cristina Baleeiro Beltrão Braga, Escola de Artes, Ciências e História, USP



SP.14 – Chemical Senses: Neurocircuits and Behavior

Chair: Deborah Schechtman, IQ-USP


Peripheral detection of odorants

Bettina Malnic, Institute of Chemistry, USP


CD36 expression in Nervous System: putative roles in an olfactory subsystem

Isaías Glezer, Federal University of São Paulo (UNIFESP)


Chemical communication between parents and offspring: molecular mechanisms of how olfaction   mediates behavioral responses towards pups in mammals.

Fabio Pappes, Universidade de Campinas (UNICAMP)


A circuit logic for taste acceptance and rejection

Ivan Eid Tavares de Araujo, Yale School of Medicine, USA



SP.15 - SBBq-Conesul Symposium: Young Researcher Platform Session 2

Chair: Alejandro Buschiazzo, Institut Pasteur de Montevideo, Uruguay


Modulation of host’s hemostatic systems by pathogenic Leptospira

Mônica Larucci Vieira, Instituto Butantan


Bacteriophytochromes from Pseudomonas syringae pv. tomato DC3000 modulate epiphytic growth and pathogenicity

Laura Moyano, Universidad Nacional de Rosario


The source of heme-dependent H2O2 generation and the importance of Na+/K+ ATPase activity to L. amazonensis biology

Nathalia Rocco Machado, Universidade Federal do Rio de Janeiro


Antimicrobial molecules in chicken eggs

Sandra Regina dos Santos, Instituto Butantan


Efficacy of 14e therapy, a furoxan derivative, in visceral leishmaniasis using hamster model of infection with Leishmania infantum and the potential of multiple targets involvement

Letícia de Almeida, Universidade Estadual de São Paulo, Araraquara



SP.16 - Argentina-Brazil Symposium: Regulation of Gene Expression in Eukaryotes (in honor to Dr. Hector Terenzi)

Chair: Gustavo H. Goldman, FCFRP-USP


Chromatin, RNA Polymerase II Elongation and Alternative Splicing

Alberto Kornbliht, Universidad de Buenos Aires, CONICET, Argentina


New therapeutic targets and prognostic tools in very aggressive types of cancer

Ernesto Podestá, Universidad de Buenos Aires, INBIOMED, Argentina


Regulatory network connecting the circadian clock and glycogen metabolism in Neurospora crassa

Maria Celia Bertolini, Instituto de Química, UNESP-Campus de Araraquara


Regulation of Aspergillus nidulans CreA-mediated catabolite repression by Fbx23 and Fbx47, F-box subunits of the SCF ubiquitin ligase complex

Gustavo H. Goldman, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP.



Sunday - July 30, 8h30 - 10h30


SP.17 - Dynamics of Biomolecular Systems

Chair: Luis Paulo Barbour Scott, UFABC


Hybrid Simulations combining Molecular Dynamics and Normal Modes:A breakthrough for the study of large scale functional properties of macromolecules

David Perahia, Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), Ecole Normale Supérieure de Cachan, France


Accounting for protein conformational populations with excited dynamics approaches

Mauricio G.S. Costa, Programa de Computação Científica – FIOCRUZ- RJ


pH and aggregation effects in the conversion of human prion into scrapie form: a study using Molecular Dynamics with excited Normal Modes

Luis Paulo Barbour Scott, Universidade Federal do ABC


New Simulation Methods in Biological Systems: from the Generalization of Boltzmann Statistics to Quantum Mechanics

Pedro Geraldo Pascutti, Instituto de Biofísica Carlos Chagas Filho, UFRJ



SP.18 - Aging and Metabolism

Chair: Marcelo Alves da Silva Mori, UNICAMP


Delaying Aging and Improving Metabolism with Drugs that Target miRNA Biogenesis

Marcelo Alves da Silva Mori, UNICAMP


Waste not, want not: a path for longevity

Fernanda Marques da Cunha, Unifesp


Targeting NAD Metabolism as Therapy for Aged Mitochondria

Juliana Camacho Pereira, Instituto de Bioquímica Médica, UFRJ


The role of SKN-1in protein homeostasis and polyglutamine aggregation in Caenorhabditiselegans

Riva de Paula Oliveira, Centro de Biociências, UFRN



SP.19 - Molecular and biochemical approaches to dissect Host-pathogen interaction

Chair: Celia R. S. Garcia, IB-USP


Hideouts and weak points in the transmission strategy of the malaria parasite Plasmodium falciparum

Pietro Alano, Instituto Superiore de Sanità, Italy


Interaction of bacterial pathogens with macrophages: intracellular receptors take the central stage

Dario Zamboni, Faculdade de Medicina de Ribeirão Preto- USP


Coxiella-containing vacuoles and Clathrin-mediated traffic

Hayley J Newton, Peter Doherty Institute for Infection and Immunity, Australia


How Decoding Signaling Pathways within host-pathogen Interaction could Lead us to Development of New Antimalarials?

Celia R. S. Garcia, IB-USP



SP.20 - New Aspects of the Kallikrein-Kinin System Activity Beyond Inflammation

Chair: Guacyara da Motta, Unifesp


Increased prekallikrein activation may decelerate biological aging

Ziaeddin Shariat-Madar, University of Mississipi, School of Pharmacy, USA


Kallikreins and temporal lobe epilepsy

Maria da Graça Naffah Mazzacoratti, UNIFESP


Kallikrein-kinin system and sleep deprivation, a nightmare?

Jair Ribeiro Chagas, Núcleo de Inovação Tecnológica, UNIFESP


Plasma Kallikrein and Cathepsin B Serum Level are Associated with Liver Fibrosis in Patients with Chronic Hepatitis C

Analúcia Rampazzo Xavier, Faculdade de Medicina da Universidade Federal Fluminense



Sunday - July 30, 11h - 12h


Conference 7

Chair: Jerson Lima da Silva, UFRJ


Imaging Brain Connectivity

Fernanda Tovar Moll, Instituto D’Or, UFRJ


Conference 8

Chair: Fernando Luís Barroso da Silva, FCFRP-USP


How to get functional information about membrane proteins using molecular dynamics simulations and bioinformatics methods: The case of red blood cell membrane proteins: the GluT1 transporter and the TSPO-VDAC complex

Catherine Etchebest

Institut National De La Santé Et De La Recherche Médicale Université Paris-Diderot


Conference 9

Chair: Russolina Zingali, UFRJ


Neurotoxicity And Membrane Disturbing Properties Of Ureases And Of Jaburetox, A Urease-Derived Peptide

Celia Carlini, Instituto de Biociências, UFRGS



Sunday - July 30, 14h - 16h


SP.21 - Nutrition, Inflammation, Obesity and Insulin Resistance

Chair: Mauro Sola-Penna, Faculdade de Farmácia, UFRJ


To be announced

Jacqueline Isaura Alvarez Leite, UFMG


Effects of natural compounds on pancreatic beta-cell physiology

Camilo Lellis-Santos, UNIFESP


Regulation of metabolism and metainflammation by nutrient sensors

William Festuccia, Instituto de Ciências Biomédicas, USP


Western diets: how long does it takes to a bad diet interfere with metabolism?

Mauro Sola-Penna, Faculdade de Farmácia, UFRJ



SP.22 - Cancer Mechanisms and Therapeutic Targets

Chair: Eduardo M. Reis, IQ-USP


Domain-focused CRISPR screening for cancer drug target identification"

Christopher Vakoc, Cold Spring Harbor Laboratory, EUA


Exploring IKKβ as an anti-angiogenic therapeutic target in KRAS-induced lung cancer

Daniela Bassères, IQ-USP


Probing the epigenome to target breast cancer

Camila dos Santos, Cold Spring Harbor Laboratory


A role for gene transfer in cancer immunotherapy: Evidence from vaccine and in situ gene therapy models

Bryan Strauss, Cancer Institute of Sao Paulo (ICESP), FMUSP



SP.23 - SBBq-Conesul Symposium: Young Researcher Platform Session 3

Chair: Marcio Ramos, Universidade Federal do Ceará


Coupling mutagenesis and functional analysis to elucidate the membrane targeting region of PlsX, a key phospholipid synthesis enzyme of Bacillus subtilis.

Diego Emiliano Sastre, Instituto de Química - USP


Deletion of secretion pathway genes results in hyper-production of target GH10 xylanase in Aspergillus nidulans

Mariane Paludetti Zubieta, Brazilian Bioethanol Science and Technology Laboratory (CTBE)


Characterization of a novel purine transporter

Mariana Barraco-Vega, Facultad de Química - Universidad de la República, Uruguay


Improved enzymatic performance of graphene immobilized Β-glucosidase A in the presence of glucose-6-phosphate.

Anderson Albino Gomes, Centro de Ciências Agroveterinárias - UDESC


The systemic RNAi pathway controls development, fertility and longevity in C. elegans

Henrique Camara, UNIFESP



SP.24 - Uruguay-Brazil Symposium: Structural Biology and Protein/Peptide Function

Chair: Leandro Barbosa, IF-USP


Molecular mechanisms of Cationic Aminoacid transporters (CATS)

Daniel Peluffo, Universidade de la Republica – Salto, Uruguay


The Impact of Group I Metabotropic Glutamate Receptors on Neuronal Excitability

Christopher Kushmerick, Universidade Federal de Minas Gerais, Brasil


A kinase:regulator complex caught in action: how bacteria switch signaling pathways on and off

Alejandro Buschiazzo, Instituto Pasteur de Montevideo, Uruguai


Structural aspects of intrinsically disordered proteins

Jose Luis Lopes, Instituto de Física, USP


Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq

Av. Prof. Lineu Prestes, 748
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