Scientific Program

 

46th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq)

 

Águas de Lindoia, São Paulo, Brazil, July 27th  to 30th, 2017

 

Scientific Program

 

Thursday – July 27th, 2017

5:30 pm to 6:00 pm - Room Real

Opening Ceremony

6:00 pm to 7:00 pm - Room Real

Opening Conference

Chair:  Richard Garratt, IFSC-USP

CryoEM of Molecular Machines at Near Atomic Resolution

Wah Chiu

Baylor College of Medicine

8:30 pm to 10:30 pm - Room Marques

Poster Session I

Friday – July 28th, 2017

8:30 am to 10:30 am – Room Rubi

8:30 am to 10:30 am –  Room  Real

Symposium 1

Modulation of Protein Kinase Function in Human Health and Plant Biotechnology

Chair: Rafael Couñago, UNICAMP

Symposium 2

Challenges for the Present and Future of Brazilian Science

Chair: Glaucius Oliva, IFSC-USP, SBBq President

Katlin Brauer Massirer,Centro de Biologia Molecular e Engenharia Genética – UNICAMP

Human kinases and RNA regulation

 

Cristiano Ruch Werneck Guimarães, Aché Laboratórios Farmacêuticos

Research, Development & (Open) Innovation at Aché Laboratórios Farmacêuticos: Exploring Understudied Kinases with the Structural Genomics Consortium

 

Elizabeth P.B. Fontes, Bioagro – UFV

Inverse modulation of antiviral and antibacterial immunity by immune RLK complexes

 

Jon Elkins, University of Oxford, UK

Chemical probe development for protein kinases STK10 and SLK

 

Mario Neto Borges, CNPq

 

 

Carlos H. Brito, FAPESP

 

 

Jorge A. Guimarães, Embrapii

 

 

 

 

8:30 am to 10:30 am –  Room Ágata

8:30 am to 10:30 am –  Room Esmeralda

Symposium 3

Diversity and Function of Microbiomes

Chair: Aline Maria da Silva, IQ-USP

Symposium 4

SBBq-GE Healthcare: 21o Prize for Young Talent in Life Science

Chair: Richard C. Garratt, IFSC-USP, SBBq Vice-President

Christian Hoffmann, Faculdade de Farmácia, USP

The Human Gut Microbiome

 

Rodrigo Mendes, Embrapa Meio Ambiente

Rhizosphere microbiome and plant disease suppression

 

Paulo Arruda, UNICAMP

Targeting new plant growth-promoting (PGP) microbes from the sugarcane microbiome

 

João Carlos Setubal, Instituto de Química, USP

A microbial-molecular view of what happens when organic waste from a Zoo is composted

 

Alan Bush, Universidad De Buenos Aires

Yeast GPCR signaling reflects the fraction of occupied receptors, not the number.

 

Leandro Vieira Dos Santos, Unicamp

From science to industry - metabolic engineering and adaptive evolution of Saccharomyces cerevisiae for second-generation (2G) ethanol production

 

Maria Belen Federico, Universidad de Buenos Aires

Independent molecular pathways control cell survival and genomic stability after UV irradiation

 

Martina Legris, Universidad de Buenos Aires

Phytochrome B Integrates Light and Temperature Signals in Arabidopsis.

 

Mychael Vinícius Da Costa Lourenço, UFRJ

FNDC5/irisin corrects memory defects in animal models of Alzheimer’s disease

10:30 am to 11:00 am – Coffee Break

Friday – July 28th, 2017

11:00 am to 12:00 pm – Room Real

11:00 am to 12:00 pm – Room Rubi

Conference 1

Chair: Anibal E. Vercesi, UNICAMP

Conference 2

Chair: Hernan F. Terenzi, UFSC

Roberto Do Campo, University of Georgia

 

Genome Editing of Protist Parasites by CRISPR/CAS9

 

Gonçalo Bernardes, University of Cambridge

 

Chemical Pharmacology of Protein Conjugates

11:00 am to 12:00 pm – Room Ágata

 

Conference 3

Chair: José Ribamar dos Santos Ferreira Júnior, EACH-USP

 

Michelina Iacovino, University of California, Los Angeles

 

Dissecting molecular mechanism of Hematopoietic Stem Cell (HSC) formation during development

 

 

12:00 pm to 1:30 pm – Lunch

1:30 pm to 3:30 pm – Room Rubi

1:30 pm to 3:30 pm – Room Ágata

Symposium 5

Structural Biology - en route towards cryo-electron microscopy

Chair: Rodrigo V. Portugal - LNNano/CNPEM / Brasil

Symposium 6

Mechanisms for Neurodegeneration and Neuroprotection: Impacts on Therapy for Degenerative Disorders.

Chair:  Maria De Fátima Dias Costa - UFBA

Richard Garratt, IFSC-USP

The Structure of the Septin Heterofilament

 

Sandra Martha Gomes Dias, LNBio/CNPEM

Active Glutaminase C Self-assembles into a Supra-tetrameric Oligomer that is Disrupted by an Allosteric Inhibitor: Implications for Cancer Metabolism

 

Mario Borgnia, NIH Molecular Microscopy Consortium at the Research Triangle Park

Conformational Variability of Macromolecular Complexes: Lessons from Cryo-EM

 

Germán Sgro, IQ-USP and Institute of Structural and Molecular Biology, UK

CryoEM structure of a bacterial killing T4SS outer membrane complex

Henning Ulrich, Institute of Chemistry, USP

Bradykinin signaling in the brain: Stimulation of neurogenesis and neuroprotection

 

 

Cláudia P. Figueiredo, Faculdade de Farmácia, UFRJ

α-Synuclein oligomers evoke non-motor and motor symptoms of Parkinson’s disease in mice

 

 

Victor Diogenes Amaral da Silva, Instituto de Ciências da Saúde, UFBA,INNT

Neurogenic, neuroprotective and immunomodulatory effects of the pro-estrogenic compound agathisflavone

Friday – July 28th, 2017

1:30 pm to 3:30 pm – Room Esmeralda

1:30 pm to 3:30 pm – Room Safira

Symposium 7

SBBq Conesul Symposium: Young Researcher Platform Session 1

Chair: Miguel Castanho, Instituto de Med.Molecular, Lisboa

Symposium 8

Phosphatases in Cancer

Chair: Fábio L. Forti, IQ-USP

Roberto Bravo-Sagua, University of Chile

Calcium-sensing receptor (CASR) activation leads to mitochondrial dysfunction in LS14 preadipocytes

 

Valentin Coppola Segovia, UFPR

Relevance of endoplasmic reticulum stress in alpha-synuclein oligomerization/aggregation in Parkinson’s Disease

 

Carolina Colleti, Universidade Federal de São Carlos

Human HSP90 structure shift by EGCG interaction

 

Thais Fernanda Bartelli, Universidade Federal de São Paulo

Experimental evolution of the pathogenic yeast Candida albicans under hypoxia and heat shock reveals that environmental conditions modifies the methylation pattern of its mitochondrial genome

 

Camila Paz López Crisosto, Univ. Chile

Mitochondrial metabolism and ER-mitochondrial coupling increase during doxycycline-induced mitochondrial stress in HeLa cells

 

Stephen M. Keyse, Ninewells Hospital & Medical School, UK

Dual-Specificity MAP kinase phosphatases are important modulators of oncogenic signalling through the Ras/ERK pathway

 

Carmen V. Ferreira, Instituto de Biologia, UNICAMP

ACP1 phosphatase as a druggable target in cancer

 

Fábio L. Forti, Instituto de Química, USP

DUSP3 phosphatase contributes for genomic stability of cancer cells

3:30 pm to 4:30 pm – Coffee with the Exhibitor

4:30 pm to 5:30 pm –  Room Real

Conference: Prêmio SBBq Leopoldo de Meis

Chair: Richard C. Garrat,USP-IFSC, Vice President of SBBq

Heparin and Heparan Sulfate: Structural and Functions Attributes still to Uncover

 Helena B. Nader

Unifesp, EPM, Brazil

5:30 pm to 7:30 pm – Poster Session II – Room Marquês

Saturday – July 29th, 2017

8:30 am to 10:30 am – Room Rubi

8:30 am to 10:30 am –  Room  Ágata

Symposium 9

Systems Biology and Biomarkers for Human Disorders

Chair: Daniel Martins-de-SouzaUNICAMP

Symposium 10

Protein and Genome Homeostasis

Chair: Carlos Henrique Inácio Ramos, UNICAMP

Giuseppe Palmisano, Instituto de Biociências, USP

Post-translational modifications in health and disease

 

Sidarta Ribeiro, Instituto do Cérebro, UFRN

Structural and Semantic Speech Analysis Provides Biomarkers of Schizophrenia, Bipolar Disorder and Alzheimer's Disease

 

Stevens Rehen, Instituto D'or de Pesquisa e Ensino and ICB-UFRJ

New insights about brain malformations using iPS cells

 

Daniel Martins-de-SouzaUNICAMP

Neuroproteomics for unravelling the molecular features of major depression

 

Walid Houry, University of Toronto, Canada of MedicinePRC Chaperoning the proteome

 

Carlos Henrique Inácio Ramos, UNICAMP

J co-chaperones: structure and interaction with the 70 kDa heat shock protein Hsp70

 

Julio Cesar Borges, USP-SC

Structure-function relationship of human mortalin – the mitochondrial Hsp70 – and the interaction with its Hep1 co-chaperone

 

Maria Isabel Nogueira Cano, UNESP

Chaperones and Leishmania spp. telomere homeostasis

Saturday – July 29th, 2017

8:30 am to 10:30 am – Room Esmeralda

8:30 am to 10:30 am – Room Safira

Symposium 11

Portugal-Brazil Symposium: Biochemisty and Molecular Biology in Science Teaching

Chair: Vera Maria Treis Trindade, UFRGS

Symposium 12

Molecular basis of demyelinating peripheral neuropathies

Chair: Flavio Alves Lara, Instituto Oswaldo Cruz, RJ

Miguel Castanho, Universidade de Lisboa, Portugal

Dealing with the challenge of building a Biochemistry Program in an integrated Medical curriculum. The need for new didactics, new focal interests, and new connections to other disciplines.

 

João Ramalho Santos, Universidade de Coimbra

The Multilayered Challenges of Contemporary Graduate Training in Biochemistry and Experimental Biology

 

Nelma Regina Segnini Bossolan, IF -São Carlos, USP

Tactile Models and Games as Learning Tools for Topics of Molecular and Cell Biology

 

Roberto Lent, Instituto de Ciências Biomédicas, UFRJ

Science For Education: A New model of Translacional Research Inspired by Education

Felipe Court, Universidad Mayor, Facultad de Ciencias, Chile

The role of vesicular transfer between glia and neurons in the regulation of axonal regeneration in the peripheral nervous system

 

Victor Tulio Rezende, IBCCF-UFRJ

Biological Behavior of Mesenchymal Stem Cells on Poli-ε-caprolactone Filaments and a Strategy for Tissue Engineering of long segments of Peripheral Nerves

 

Pedro José Tomaselli, FMRP-USP

Guillain-Barré Syndrome and Variants Associated with Zika Virus

 

Flavio Alves Lara, Instituto Oswaldo Cruz, RJ

Central Metabolism as a New Target in the Control of Leprosy Neuropathy

10:30 am to 11:00 am – Coffee Break

11:00 am to 12:00 pm – Room Real

11:00 am to 12:00 pm – Room Rubi

Conference 4

Chair: Marcio Dias, ICB-USP

Conference 5

Chair: Paulo Arruda, UNICAMP

Ben F. LuisiUniversity of Cambridge-UK

The structure and mechanism of bacterial multi-drug efflux pumps

Opher Gileadi, University of Oxford/ UNICAMP.

From disease genetics to chemical intervention: Overcoming barriers to the discovery of novel drug targets


Saturday – July 29th, 2017

11:00 am to 12:00 pm – Room Ágata

 

Conference 6

Chair: Gabriel Horninck, Unifal

 

Eduardo Galembeck, UNICAMP

The Internet of things, mobile devices and the promising future for Science Education

 

12:00 pm to 1:30 pm – Lunch  

1:30 pm to 3:30 pm – Room Rubi

1:30 pm to 3:30 pm – Room Ágata

Symposium 13

Zika virus: Structural, Immunological and neurological aspects

Chair: Glaucius Oliva, IFSC-USP

Symposium 14

Chemical Senses: Neurocircuits and Behavior

Chair: Deborah Schechtman, IQ-USP

Jerson Lima da Silva, Instituto de Bioquímica Médica, UFRJ

Structural and Immunological Properties of Inactivated Zika Virus Particles

 

Lucas Bleicher, UFMG

Detecting important positions in flaviviruses proteins by statistical analysis of conserved domains

 

Glaucius Oliva, Instituto de Física de São Carlos, USP

Crystal structure of Zika virus RNA-dependent RNA-polymerase

 

Patrícia Cristina B. B. Braga, EACH, USP

The Use of Brain Organoids to Measure the Impact of Zika Virus on Microcephaly

Bettina Malnic, Institute of Chemistry, USP

Peripheral detection of odorants

 

Isaías Glezer, Federal University of São Paulo, UNIFESP

CD36 expression in Nervous System: putative roles in an olfactory subsystem

 

Fabio Pappes, IB-UNICAMP

Chemical communication between parents and offspring: molecular mechanisms of how olfaction   mediates behavioral responses towards pups in mammals.

 

Ivan Eid Tavares de Araujo, Yale School of Medicine, USA

A circuit logic for taste acceptance and rejection

1:30 pm to 3:30 pm – Room Esmeralda

1:30 pm to 3:30 pm – Safira

Symposium 15

SBBq-Conesul Symposium: Young Researcher Platform Session

Chair: Alejandro Buschiazzo, Inst Pasteur de Montevideo

Symposium 16: Argentina-Brazil Symposium: Regulation of Gene Expression in Eukaryotes (in honor to Dr. Hector Terenzi)

Chair: Gustavo H. Goldman, FCFRP-USP

Mônica Larucci Vieira, Instituto Butantan

Modulation of host’s hemostatic systems by pathogenic Leptospira

 

Laura Moyano, Universidad Nacional de Rosario

Bacteriophytochromes from Pseudomonas syringae pv. tomato DC3000 modulate epiphytic growth and pathogenicity

 

Nathalia Rocco Machado, UFRJ

The source of heme-dependent H2O2 generation and the importance of Na+/K+ ATPase activity to L. amazonensis biology

 

Sandra Regina dos Santos, Instituto Butantan

Antimicrobial molecules in chicken eggs

 

Letícia de Almeida, Unesp, Araraquara

Efficacy of 14e therapy, a furoxan derivative, in visceral leishmaniasis using hamster model of infection with L.infantum and the potential of multiple targets involvement

Alberto Kornbliht, Univ. de Buenos Aires, CONICET, Argentina

Chromatin, RNA Polymerase II Elongation and Alternative Splicing

 

Ernesto Podestá, Univ. de Buenos Aires, INBIOMED, Argentina

New therapeutic targets and prognostic tools in very aggressive types of cancer

 

Maria Celia Bertolini, IQ, UNESP, Campus de Araraquara

Regulatory network connecting the circadian clock and glycogen metabolism in Neurospora crassa

 

Gustavo H. Goldman, FCFRP, USP

Regulation of Aspergillus nidulans CreA-mediated catabolite repression by Fbx23 and Fbx47, F-box subunits of the SCF ubiquitin ligase complex

4:00 pm to 5:00 pm – Coffee with the Exhibitor

5:00 pm to 7:00 pm – Poster Session II – Room Marquês

7:00 pm to 8:00 pm – SBBq General Assembly – All participants are invited (in Portuguese) – Room Rubi

Sunday – July 30th, 2017

8:30 am to 10:30 am – Room Rubi

8:30 am to 10:30 am – Room Ágata

Symposium 17

Dynamics of Biomolecular Systems

Chair: Luis Paulo Barbour Scott, UFABC

Symposium 18

Aging and Metabolism

Chair: Marcelo Alves da Silva Mori, UNICAMP

David Perahia, LBPA, Ecole Normale Supérieure de Cachan, France

Hybrid Simulations combining Molecular Dynamics and Normal Modes:A breakthrough for the study of large scale functional properties of macromolecules

 

Mauricio G.S. Costa, FIOCRUZ, RJ

Accounting for protein conformational populations with excited dynamics approaches

 

Luis Paulo Barbour Scott, Universidade Federal do ABC

pH and aggregation effects in the conversion of human prion into scrapie form: a study using Molecular Dynamics with excited Normal Modes

 

Pedro Geraldo Pascutti, IBCCF, UFRJ

New Simulation Methods in Biological Systems: from the Generalization of Boltzmann Statistics to Quantum Mechanics

Marcelo Alves da Silva Mori, UNICAMP

 

Delaying Aging and Improving Metabolism with Drugs that Target miRNA Biogenesis

 

Fernanda Marques da Cunha, Unifesp

Waste not, want not: a path for longevity

 

 

Juliana Camacho Pereira, Inst. de Bioquímica Médica, UFRJ

Targeting NAD Metabolism as Therapy for Aged Mitochondria

 

Riva de Paula Oliveira, Centro de Biociências, UFRN

The role of SKN-1in protein homeostasis and polyglutamine aggregation in Caenorhabditis elegans

8:30 am to 10:30 am – Room Esmeralda

8:30 am to 10:30 am – Room Safira

Symposium 19

Molecular and biochemical approaches to dissect Host-pathogen interaction

Chair: Celia R. S. Garcia, IB-USP

 

Pietro Alano, Instituto Superiore de Sanità, Italy

Hideouts and weak points in the transmission strategy of the malaria parasite Plasmodium falciparum

 

Dario Zamboni, Fac. de Medicina de Ribeirão Preto- USP

Interaction of bacterial pathogens with macrophages: intracellular receptors take the central stage

 

Hayley J Newton, Peter Doherty Institute for Infection and Immunity, Australia

Coxiella-containing vacuoles and Clathrin-mediated traffic

 

Celia R. S. Garcia, IB-USP

How Decoding Signaling Pathways within host-pathogen Interaction could Lead us to Development of New Antimalarials?

 

Symposium 20

New Aspects of the Kallikrein-Kinin System Activity Beyond Inflammation

Chair: Guacyara da Motta, Unifesp

 

Ziaeddin Shariat-Madar, University of Mississippi, School of Pharmacy, USA

Increased pre kallikrein activation may decelerate biological aging

 

Maria da Graça Naffah Mazzacoratti, UNIFESP

Kallikreins and temporal lobe epilepsy

 

Jair Ribeiro Chagas, Núcleo de Inovação Tecnológica, UNIFESP

Kallikrein-kinin system and sleep deprivation, a nightmare?

 

Analúcia Rampazzo Xavier, Fac. de Medicina, UFF, RJ

Plasma Kallikrein and Cathepsin B Serum Level are Associated with Liver Fibrosis in Patients with Chronic Hepatitis C

10:30 am to 11:00 am – Coffee Break     

11:00 am to 12:00 pm – Room Real

11:00 am to 12:00 pm – Room Rubi

Conference 7

Chair: Jerson Lima da Silva, UFRJ

Conference 8

Chair: Fernando Luís Barroso da Silva, FCFRP-USP

Fernanda Tovar Moll, Instituto D’Or, UFRJ

 

Imaging Brain Connectivity

Catherine Etchebest, Institut National De La Santé Et De La Recherche Médicale Université Paris-Diderot

 

How to get functional information about membrane proteins using molecular dynamics simulations and bioinformatics methods: The case of red blood cell membrane proteins: the GluT1 transporter and the TSPO-VDAC complex

Sunday – July 30th, 2017

11:00 am to 12:00 pm – Room Ágata

 

Conference 9

Chair: Russolina Zingali, UFRJ

 

Celia Carlini, Instituto de Biociências, UFRGS

 

Neurotoxicity and Membrane Disturbing Properties of Ureases And of Jaburetox, A Urease-Derived Peptide

 

12:00 pm to 1:30 pm – Lunch

1:30 pm to 3:30 pm – Room Rubi

1:30 pm to 3:30 pm – Room Ágata

Symposium 21

Nutrition, Inflammation, Obesity and Insulin Resistance

Chair: Mauro Sola-Penna, Faculdade de Farmácia, UFRJ

Symposium 22

Cancer Mechanisms and Therapeutic Targets

Chair: Eduardo M. Reis, IQ-USP

Jacqueline Isaura Alvarez Leite, UFMG

Gluten and obesity: Metabolic and Clinical Perspectives

 

Camilo Lellis-Santos, UNIFESP

Effects of natural compounds on pancreatic beta-cell physiology

 

William Festuccia, Instituto de Ciências Biomédicas, USP

Regulation of metabolism and metainflammation by nutrient sensors

 

Mauro Sola-Penna, Faculdade de Farmácia, UFRJ

Western diets: how long does it takes to a bad diet interfere with metabolism?

Christopher Vakoc, Cold Spring Harbor Laboratory, EUA

Domain-focused CRISPR screening for cancer drug target identification"

 

Daniela Bassères, IQ-USP

Exploring IKKβ as an anti-angiogenic therapeutic target in KRAS-induced lung cancer

 

Camila dos Santos, Cold Spring Harbor Laboratory

Probing the epigenome to target breast cancer

 

Bryan Strauss, Cancer Institute of Sao Paulo (ICESP), FMUSP

A role for gene transfer in cancer immunotherapy: Evidence from vaccine and in situ gene therapy models

1:30 pm to 3:30 pm – Room Esmeralda

1:30 pm to 3:30 pm – Room Safira

Symposium 23

SBBq-Conesul Symposium: Young Researcher Platform Session

Chair: Marcio Ramos, Universidade Federal do Ceará

 

Diego Emiliano Sastre, Instituto de Química - USP

Coupling mutagenesis and functional analysis to elucidate the membrane targeting region of PlsX, a key phospholipid synthesis enzyme of Bacillus subtilis.

 

Mariane Paludetti Zubieta, Brazilian Bioethanol Science and Deletion of secretion pathway genes results in hyper-production of target GH10 xylanase in Aspergillus nidulans

 

Mariana Barraco-Vega, Facultad de Química - Universidad de la República, Uruguay

Characterization of a novel purine transporter

 

Anderson Albino Gomes, Centro de Ciências Agroveterinárias - UDESC

Improved enzymatic performance of graphene immobilized Β-glucosidase A in the presence of glucose-6-phosphate.

 

Henrique Camara, UNIFESP

The systemic RNAi pathway controls development, fertility and longevity in C. elegans

Symposium 24

Uruguay-Brazil Symposium: Structural Biology and Protein/Peptide Function

Chair: Leandro Barbosa, IF-USP

 

Daniel Peluffo, Universidade de la Republica – Salto, Uruguay

Molecular mechanisms of Cationic Aminoacid transporters (CATS)

 

Alejandro Buschiazzo, Instituto Pasteur de Montevideo, Uruguai

A kinase:regulator complex caught in action: how bacteria switch signaling pathways on and off

 

Jose Luis Lopes, Instituto de Física, USP

Structural aspects of intrinsically disordered proteins

 

Leandro Barbosa, Instituto de Física, USP

Studying the interaction of ionic liquids and biologically relevant system

 

3:30 pm to 4:00 pm – Coffee BreakRoom Real

 

4:00 pm to 5:00 pm – Room Real

Closing Ceremony and Awards

SBBQ Award: Posters presented during the Annual Meeting and that have applied to compete for the SBBq award will be evaluated by a committee of experts and the best posters will be nominated to receive the SBBq Award

 

21st Young Talent Award for Life Sciences.

 

Biozeus Award.

 

Bayardo B. Torres National Award for Teaching Biochemistry and Molecular Biology.

     


 
 
 
SBBq

Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq

Av. Prof. Lineu Prestes, 748
Bloco 3 superior, Sala 0367
Cep 05508-000
Butantã – São Paulo, SP

Telefone/fax: (011) 3815-5798

e-mail: congress@sbbq.org.br