Scientific Program

46ª SBBq Annual Meeting

27th to 30th July, 2017

Final Program - click to download

 

Thursday - July 27

8h - 16h: Mini-Courses

MC1: RNA therapeutics

Karen Cristiane Martinez de Moraes, IB–UNESP, Rio Claro.

 

MC2: Analysis of protein families using sequence alignment tools and site-directed mutagenesis

Lucas Bleicher, UFMG

 

MC3: Advanced mass spectrometry-based proteomics for post-translational modifications (PTMs) analysis

Jose Cesar Rosa, FMRP-USP and Giuseppe Palmisano, IB-USP

 

MC4: Use of Information and knowledge technologies in experimental biochemistry classes

Guilherme Marson, IQ-USP

 

MC5: Ludic development of android applications as a teaching strategy

Gabriel Hornink, Unifal, Minas Gerais

 

MC6: Introduction to cryo-electron microscopy

Marin Van Heel, Imperial College London and Rodrigo V. Portugal (LNNano/CNPEM)

 

16h30 - 17h30: Short-talk

An enterprising scientist in the scientific communication startup “Mind the Graph”

Fabricio Pamplona, Founder.

 

18h -19h:  Opening Conference

Chair:  Richard Garratt, IFSC-USP

 

CryoEM of Molecular Machines at Near Atomic Resolution

Wah Chiu, Baylor College of Medicine

 

Friday - July 28, 8h30 - 10h30

 

SP.01 – Modulation of Protein Kinase Function in Human Health and Plant Biotechnology

Chair: Rafael Counago, UNICAMP

 

Human kinases and RNA regulation

Katlin Brauer Massirer,Centro de Biologia Molecular e Engenharia Genética – UNICAMP

 

Research, Development & (Open) Innovation at Aché Laboratórios Farmacêuticos: Exploring Understudied Kinases with the Structural Genomics Consortium

Cristiano Ruch Werneck Guimarães, Aché Laboratórios Farmacêuticos

 

Inverse modulation of antiviral and antibacterial immunity by immune RLK complexes

Elizabeth P B Fontes, Bioagro - Universidade Federal de Viçosa

 

Chemical probe development for protein kinases STK10 and SLK

Jon Elkins, University of Oxford, UK

 

SP.02 - Challenges for the Present and Future of Brazilian Science

Chair: Glaucius Oliva, IFSC-USP, SBBq President

 

Mario Neto Borges, CNPq

Carlos H. Brito, FAPESP

Jorge A. Guimarães, Embrapii

 

SP.03 – Diversity and Function of Microbiomes

Chair: Aline Maria da Silva, IQ-USP

 

A microbial-molecular view of what happens when organic waste from a Zoo is composted

João Carlos Setubal, Instituto de Química, USP

 

Rhizosphere microbiome and plant disease suppression

Rodrigo Mendes, Embrapa Meio Ambiente

  

Targeting new plant growth-promoting (PGP) microbes from the sugarcane microbiome

Paulo Arruda, UNICAMP

 

The Human Gut Microbiome

Christian Hoffmann, Faculdade de Farmácia, USP

 

SP.04 - SBBq-GE Healthcare: 21o Prize for Young Talent in Life Science

Chair: Richard C. Garratt, IFSC-USP, SBBq Vice-President

 

Yeast GPCR signaling reflects the fraction of occupied receptors, not the number.

Alan Bush, Universidad De Buenos Aires

 

From science to industry - metabolic engineering and adaptive evolution of Saccharomyces cerevisiae for second-generation (2G) ethanol production

Leandro Vieira Dos Santos, Universidade Estadual de Campinas

 

Independent molecular pathways control cell survival and genomic stability after UV irradiation

Maria Belen Federico, Universidad de Buenos Aires

 

Phytochrome B Integrates Light and Temperature Signals in Arabidopsis.

Martina Legris, Universidad de Buenos Aires

 

FNDC5/irisin corrects memory defects in animal models of Alzheimer’s disease

Mychael Vinícius Da Costa Lourenço, Universidade Federal do Rio De Janeiro

 

Friday - July 28,11h – 12h

 

Conference 1

Chair: Anibal E. Vercesi, UNICAMP

 

Genome Editing of Protist Parasites by CRISPR/CAS9

Roberto Do Campo, University of Georgia

 

Conference 2

Chair: Hernan F. Terenzi, UFSC

 

Chemical Pharmacology of Protein Conjugates

Gonçalo Bernardes, University of Cambridge

 

Conference 3

Chair: José Ribamar dos Santos Ferreira Júnior, EACH-USP

 

Dissecting molecular mechanism of Hematopoietic Stem Cell (HSC) formation during development

Michelina Iacovino, University of California, Los Angeles

 

Friday - July 28, 14h - 16h

 

SP.05 - Structural Biology - en route towards cryo-electron microscopy

Chair: Rodrigo V. Portugal - LNNano/CNPEM / Brasil

 

The Structure of the Septin Heterofilament

Richard Garratt - IFSC-USP / Brasil

 

Active Glutaminase C Self-assembles into a Supra-tetrameric Oligomer that is Disrupted by an Allosteric Inhibitor: Implications for Cancer Metabolism

Sandra Martha Gomes Dias - LNBio/CNPEM / Brasil

  

Conformational Variability of Macromolecular Complexes: Lessons from Cryo-EM

Mario Borgnia - NIH Molecular Microscopy Consortium at the Research Triangle Park,  USA

 

CryoEM structure of a bacterial killing T4SS outer membrane complex

Germán Sgro, Institute of Structural and Molecular Biology – Birkbeck/UCL, UK

 

 

SP.06 – Mechanisms for Neurodegeneration and Neuroprotection: Impacts on Therapy for Degenerative Disorders.

Chair:  Maria De Fátima Dias Costa (UFBA)

 

Bradykinin signaling in the brain: Stimulation of neurogenesis and neuroprotection

Henning Ulrich, Institute of Chemistry, USP

 

α-Synuclein oligomers evoke non-motor and motor symptoms of Parkinson’s disease in mice

Cláudia P. Figueiredo, Faculdade de Farmácia, UFRJ

 

Neuroprotective role of guanosine in brain injury

Diogo Onofre de Souza, UFRGS

 

Neurogenic, neuroprotective and immunomodulatory effects of the pro-estrogenic compound agathisflavone

Victor Diogenes Amaral da Silva, Instituto de Ciências da Saúde, UFBA,INNT

 

 

SP.07 –SBBq Conesul Symposium: Young Researcher Platform Session 1

Chair: Miguel Castanho, Instituto de Medicina Molecular, Lisbon, Portugal

 

Calcium-sensing receptor (CASR) activation leads to mitochondrial dysfunction in LS14 preadipocytes

Roberto Bravo-Sagua, University of Chile

 

Relevance of endoplasmic reticulum stress in alpha-synuclein oligomerization/aggregation in Parkinson’s Disease

Valentin Coppola Segovia, Universidade Federal do Paraná

 

Human HSP90 structure shift by EGCG interaction

Carolina Colleti, Universidade Federal de São Carlos

 

Experimental evolution of the pathogenic yeast Candida albicans under hypoxia and heat shock reveals that environmental conditions modifies the methylation pattern of its mitochondrial genome

Thais Fernanda Bartelli, Universidade Federal de São Paulo

 

Mitochondrial metabolism and ER-mitochondrial coupling increase during doxycycline-induced mitochondrial stress in HeLa cells

Camila Paz López Crisosto, Univ. Chile

 

 

SP.08 – Phosphatases in Cancer

Chair: Fábio L. Forti, IQ-USP

 

Dual-Specificity MAP kinase phosphatases are important modulators of oncogenic signalling through the Ras/ERK pathway

Stephen M. Keyse, Division of Cancer Research, Ninewells Hospital & Medical School, UK

 

ACP1 phosphatase as a druggable target in cancer

Carmen V. Ferreira, Instituto de Biologia, UNICAMP

 

Dual-specificity phosphatases in metabolic reprogramming of pancreatic cancer

Vanessa S. Silveira, Faculdade de Medicina de Ribeirão Preto, USP

 

DUSP3 phosphatase contributes for genomic stability of cancer cells

Fábio L. Forti, Instituto de Química, USP

 

 

Saturday - July 29, 8h30 - 10h30

 

SP.09 – Systems Biology and Biomarkers for Human Disorders

Chair: Daniel Martins-de-Souza, UNICAMP

 

Post-translational modifications in health and disease

Giuseppe Palmisano, Instituto de Biociências, USP

 

Molecular signatures of Parkinson’s Alzheimer’s and Bipolar diseases: Altered Regulons, Molecular Targets and Innovative Therapeutics Interventions

Fabio Klamt, Instituto de Ciências Básicas da Saúde, UFRGS

 

Structural and Semantic Speech Analysis Provides Biomarkers of Schizophrenia, Bipolar Disorder and Alzheimer's Disease

Sidarta Ribeiro, Instituto do Cérebro, UFRN

 

New insights about brain malformations using iPS cells

Stevens Rehen, Instituto D'or de Pesquisa e Ensino and ICB-UFRJ

 

 

SP.10 - Protein and Genome Homeostasis

Chair: Carlos Henrique Inácio Ramos, UNICAMP

 

Chaperoning the proteome

Walid Houry, University of Toronto, Canada

 

J co-chaperones: structure and interaction with the 70 kDa heat shock protein Hsp70

Carlos Henrique Inácio Ramos, UNICAMP

 

Structure-function relationship of human mortalin – the mitochondrial Hsp70 – and the interaction with its Hep1 co-chaperone

Julio Cesar Borges, USP-SC

 

Chaperones and Leishmania spp. telomere homeostasis

Maria Isabel Nogueira Cano, UNESP

 

 

SP.11 – Portugal-Brazil Symposium: Biochemistry and Molecular Biology in Science Teaching

Chair: Vera Maria Treis Trindade, UFRGS

 

Dealing with the challenge of building a Biochemistry Program in an integrated Medical curriculum. The need for new didactics, new focal interests, and new connections to other disciplines.

Miguel Castanho, Faculdade de Medicina, Universidade de Lisboa, Lisboa

 

The Multilayered Challenges of Contemporary Graduate Training in Biochemistry and Experimental Biology

João Ramalho Santos, Universidade de Coimbra

 

Tactile Models and Games as Learning Tools for Topics of Molecular and Cell Biology

Nelma Regina Segnini Bossolan, Instituto de Fisíca de São Carlos, USP

 

Science For Education: A New model of Translacional Research Inspired by Education

Roberto Lent, Instituto de Ciências Biomédicas, UFRJ

 

 

SP.12 – Molecular basis of demyelinating peripheral neuropathies

Chair: Flavio Alves Lara, Instituto Oswaldo Cruz, RJ

 

The role of vesicular transfer between glia and neurons in the regulation of axonal regeneration in the peripheral nervous system

Felipe Court, Universidad Mayor, Facultad de Ciencias, Chile

 

Biological Behavior of Mesenchymal Stem Cells on Poli-ε-caprolactone Filaments and a Strategy for Tissue Engineering of long segments of Peripheral Nerves

Victor Tulio Rezende, IBCCF-UFRJ

 

Peripheral neuropathy associated to Zika virus.

Fernando Bozza, Instituto Nacional de Infectologia Evandro Chaves, Fiocruz

  

Central Metabolism as a New Target in the Control of Leprosy Neuropathy

Flavio Alves Lara, Instituto Oswaldo Cruz, RJ

 

 

Saturday - July 29, 11h – 12h

 

Conference 4

Chair: Marcio Dias, ICB-USP

 

The structure and mechanism of bacterial multi-drug efflux pumps

Ben F. Luisi, University of Cambridge-UK

 

Conference 5

Chair: Paulo Arruda, UNICAMP

 

From disease genetics to chemical intervention: Overcoming barriers to the discovery of novel drug targets

Opher Gileadi, Structural Genomics Consortium, University of Oxford/ UNICAMP.

 

Conference 6

Chair: Gabriel Horninck, Unifal

 

The Internet of things, mobile devices and the promising future for Science Education

Eduardo Galembeck, UNICAMP

 

 

Saturday - July 29,14h - 16h

 

SP.13 – Zika virus: Structural, Immunological and neurological aspects

Chair: Glaucius Oliva, IFSC-USP

 

Structural and Immunological Properties of Inactivated Zika Virus Particles

Jerson Lima da Silva, Instituto de Bioquímica Médica, UFRJ

 

Detecting important positions in flaviviruses proteins by statistical analysis of conserved domains

Lucas Bleicher, UFMG

 

Crystal structure of Zika virus RNA-dependent RNA-polymerase

Glaucius Oliva, Instituto de Física de São Carlos, USP

 

The Use of Brain Organoids to Measure the Impact of Zika Virus on Microcephaly

Patrícia Cristina Baleeiro Beltrão Braga, Escola de Artes, Ciências e História, USP

 

 

SP.14 – Chemical Senses: Neurocircuits and Behavior

Chair: Deborah Schechtman, IQ-USP

 

Peripheral detection of odorants

Bettina Malnic, Institute of Chemistry, USP

 

CD36 expression in Nervous System: putative roles in an olfactory subsystem

Isaías Glezer, Federal University of São Paulo (UNIFESP)

 

Chemical communication between parents and offspring: molecular mechanisms of how olfaction   mediates behavioral responses towards pups in mammals.

Fabio Pappes, Universidade de Campinas (UNICAMP)

 

A circuit logic for taste acceptance and rejection

Ivan Eid Tavares de Araujo, Yale School of Medicine, USA

 

 

SP.15 - SBBq-Conesul Symposium: Young Researcher Platform Session 2

Chair: Alejandro Buschiazzo, Institut Pasteur de Montevideo, Uruguay

 

Modulation of host’s hemostatic systems by pathogenic Leptospira

Mônica Larucci Vieira, Instituto Butantan

 

Bacteriophytochromes from Pseudomonas syringae pv. tomato DC3000 modulate epiphytic growth and pathogenicity

Laura Moyano, Universidad Nacional de Rosario

 

The source of heme-dependent H2O2 generation and the importance of Na+/K+ ATPase activity to L. amazonensis biology

Nathalia Rocco Machado, Universidade Federal do Rio de Janeiro

 

Antimicrobial molecules in chicken eggs

Sandra Regina dos Santos, Instituto Butantan

 

Efficacy of 14e therapy, a furoxan derivative, in visceral leishmaniasis using hamster model of infection with Leishmania infantum and the potential of multiple targets involvement

Letícia de Almeida, Universidade Estadual de São Paulo, Araraquara

 

 

SP.16 - Argentina-Brazil Symposium: Regulation of Gene Expression in Eukaryotes (in honor to Dr. Hector Terenzi)

Chair: Gustavo H. Goldman, FCFRP-USP

 

Chromatin, RNA Polymerase II Elongation and Alternative Splicing

Alberto Kornbliht, Universidad de Buenos Aires, CONICET, Argentina

 

New therapeutic targets and prognostic tools in very aggressive types of cancer

Ernesto Podestá, Universidad de Buenos Aires, INBIOMED, Argentina

 

Regulatory network connecting the circadian clock and glycogen metabolism in Neurospora crassa

Maria Celia Bertolini, Instituto de Química, UNESP-Campus de Araraquara

  

Regulation of Aspergillus nidulans CreA-mediated catabolite repression by Fbx23 and Fbx47, F-box subunits of the SCF ubiquitin ligase complex

Gustavo H. Goldman, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP.

 

 

Sunday - July 30, 8h30 - 10h30

 

SP.17 - Dynamics of Biomolecular Systems

Chair: Luis Paulo Barbour Scott, UFABC

 

Hybrid Simulations combining Molecular Dynamics and Normal Modes:A breakthrough for the study of large scale functional properties of macromolecules

David Perahia, Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), Ecole Normale Supérieure de Cachan, France

 

Accounting for protein conformational populations with excited dynamics approaches

Mauricio G.S. Costa, Programa de Computação Científica – FIOCRUZ- RJ

 

pH and aggregation effects in the conversion of human prion into scrapie form: a study using Molecular Dynamics with excited Normal Modes

Luis Paulo Barbour Scott, Universidade Federal do ABC

 

New Simulation Methods in Biological Systems: from the Generalization of Boltzmann Statistics to Quantum Mechanics

Pedro Geraldo Pascutti, Instituto de Biofísica Carlos Chagas Filho, UFRJ

 

 

SP.18 - Aging and Metabolism

Chair: Marcelo Alves da Silva Mori, UNICAMP

 

Delaying Aging and Improving Metabolism with Drugs that Target miRNA Biogenesis

Marcelo Alves da Silva Mori, UNICAMP

  

Waste not, want not: a path for longevity

Fernanda Marques da Cunha, Unifesp

  

Targeting NAD Metabolism as Therapy for Aged Mitochondria

Juliana Camacho Pereira, Instituto de Bioquímica Médica, UFRJ

  

The role of SKN-1in protein homeostasis and polyglutamine aggregation in Caenorhabditiselegans

Riva de Paula Oliveira, Centro de Biociências, UFRN

 

 

SP.19 - Molecular and biochemical approaches to dissect Host-pathogen interaction

Chair: Celia R. S. Garcia, IB-USP

 

Hideouts and weak points in the transmission strategy of the malaria parasite Plasmodium falciparum

Pietro Alano, Instituto Superiore de Sanità, Italy

 

Interaction of bacterial pathogens with macrophages: intracellular receptors take the central stage

Dario Zamboni, Faculdade de Medicina de Ribeirão Preto- USP

 

Coxiella-containing vacuoles and Clathrin-mediated traffic

Hayley J Newton, Peter Doherty Institute for Infection and Immunity, Australia

 

How Decoding Signaling Pathways within host-pathogen Interaction could Lead us to Development of New Antimalarials?

Celia R. S. Garcia, IB-USP

 

 

SP.20 - New Aspects of the Kallikrein-Kinin System Activity Beyond Inflammation

Chair: Guacyara da Motta, Unifesp

 

Increased prekallikrein activation may decelerate biological aging

Ziaeddin Shariat-Madar, University of Mississipi, School of Pharmacy, USA

 

Kallikreins and temporal lobe epilepsy

Maria da Graça Naffah Mazzacoratti, UNIFESP

 

Kallikrein-kinin system and sleep deprivation, a nightmare?

Jair Ribeiro Chagas, Núcleo de Inovação Tecnológica, UNIFESP

 

Plasma Kallikrein and Cathepsin B Serum Level are Associated with Liver Fibrosis in Patients with Chronic Hepatitis C

Analúcia Rampazzo Xavier, Faculdade de Medicina da Universidade Federal Fluminense

 

 

Sunday - July 30, 11h - 12h

 

Conference 7

Chair: Jerson Lima da Silva, UFRJ

 

Imaging Brain Connectivity

Fernanda Tovar Moll, Instituto D’Or, UFRJ

 

Conference 8

Chair: Fernando Luís Barroso da Silva, FCFRP-USP

 

How to get functional information about membrane proteins using molecular dynamics simulations and bioinformatics methods: The case of red blood cell membrane proteins: the GluT1 transporter and the TSPO-VDAC complex

Catherine Etchebest

Institut National De La Santé Et De La Recherche Médicale Université Paris-Diderot

 

Conference 9

Chair: Russolina Zingali, UFRJ

 

Neurotoxicity And Membrane Disturbing Properties Of Ureases And Of Jaburetox, A Urease-Derived Peptide

Celia Carlini, Instituto de Biociências, UFRGS

 

 

Sunday - July 30, 14h - 16h

 

SP.21 - Nutrition, Inflammation, Obesity and Insulin Resistance

Chair: Mauro Sola-Penna, Faculdade de Farmácia, UFRJ

 

To be announced

Jacqueline Isaura Alvarez Leite, UFMG

 

Effects of natural compounds on pancreatic beta-cell physiology

Camilo Lellis-Santos, UNIFESP

 

Regulation of metabolism and metainflammation by nutrient sensors

William Festuccia, Instituto de Ciências Biomédicas, USP

 

Western diets: how long does it takes to a bad diet interfere with metabolism?

Mauro Sola-Penna, Faculdade de Farmácia, UFRJ

 

 

SP.22 - Cancer Mechanisms and Therapeutic Targets

Chair: Eduardo M. Reis, IQ-USP

 

Domain-focused CRISPR screening for cancer drug target identification"

Christopher Vakoc, Cold Spring Harbor Laboratory, EUA

 

Exploring IKKβ as an anti-angiogenic therapeutic target in KRAS-induced lung cancer

Daniela Bassères, IQ-USP

 

Probing the epigenome to target breast cancer

Camila dos Santos, Cold Spring Harbor Laboratory

 

A role for gene transfer in cancer immunotherapy: Evidence from vaccine and in situ gene therapy models

Bryan Strauss, Cancer Institute of Sao Paulo (ICESP), FMUSP

 

 

SP.23 - SBBq-Conesul Symposium: Young Researcher Platform Session 3

Chair: Marcio Ramos, Universidade Federal do Ceará

 

Coupling mutagenesis and functional analysis to elucidate the membrane targeting region of PlsX, a key phospholipid synthesis enzyme of Bacillus subtilis.

Diego Emiliano Sastre, Instituto de Química - USP

 

Deletion of secretion pathway genes results in hyper-production of target GH10 xylanase in Aspergillus nidulans

Mariane Paludetti Zubieta, Brazilian Bioethanol Science and Technology Laboratory (CTBE)

 

Characterization of a novel purine transporter

Mariana Barraco-Vega, Facultad de Química - Universidad de la República, Uruguay

 

Improved enzymatic performance of graphene immobilized Β-glucosidase A in the presence of glucose-6-phosphate.

Anderson Albino Gomes, Centro de Ciências Agroveterinárias - UDESC

 

The systemic RNAi pathway controls development, fertility and longevity in C. elegans

Henrique Camara, UNIFESP

 

 

SP.24 - Uruguay-Brazil Symposium: Structural Biology and Protein/Peptide Function

Chair: Leandro Barbosa, IF-USP

 

Molecular mechanisms of Cationic Aminoacid transporters (CATS)

Daniel Peluffo, Universidade de la Republica – Salto, Uruguay

 

The Impact of Group I Metabotropic Glutamate Receptors on Neuronal Excitability

Christopher Kushmerick, Universidade Federal de Minas Gerais, Brasil

 

A kinase:regulator complex caught in action: how bacteria switch signaling pathways on and off

Alejandro Buschiazzo, Instituto Pasteur de Montevideo, Uruguai

 

Structural aspects of intrinsically disordered proteins

Jose Luis Lopes, Instituto de Física, USP



 
 
 
SBBq

Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq

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Butantã – São Paulo, SP

Telefone/fax: (011) 3815-5798

e-mail: congress@sbbq.org.br